Introduction

• Human monoclonal IgG4 antibody inhibiting interleukin-4 (IL-4) and interleukin-13 (IL-13)
• Dupixent 300mg/2mL prefilled syringe

Dosing

• 600mg subcut loading dose (week 0), then 300mg every 2 weeks

PBS quantity

• Initial: 2 * 300mg (1 box), 5 repeats (~6 months supply)
• Continuing:: 2 * 300mg (1 box), 5 repeats (6 months supply)

Mechanism of action

Indications

Side effects

• Injection site reaction
• Ocular surface disorders:
  • Conjunctivitis, blepharitis, keratitis (rare), eye pruritus, and dry eye syndrome.
  • Rare cases of severe cicatrizing blepharoconjunctivitis have occured.
  • Severe atopic dermatitis increases risk of ocular side effects